Covid-19: New mutation of Indian variant under close watch in UK

Officials are keeping a close watch on a new descendant of the Delta variant of Covid that is causing a growing number of infections.

Delta is the UK’s dominant variant, but latest official data suggests 6% of Covid cases that have been genetically sequenced are of a new type.

AY.4.2, which some are calling “Delta Plus”, contains mutations that might give the virus survival advantages.

Tests are under way to understand how much of a threat it may pose.

Experts say it is unlikely to take off in a big way or escape current vaccines.

It is not yet considered a variant of concern, or a variant under investigation – the categories assigned to variants and the level of risk associated with them.

What is AY.4.2?

There are thousands of different types – or variants – of Covid circulating across the world. Viruses mutate all the time, so it is not surprising to see new versions emerge.

Original Delta was classified as a variant of concern in the UK in May 2021 after overtaking the Alpha variant to become the dominant type of Covid in circulation.

But in July 2021 experts identified AY.4.2.

This offshoot or sublineage of Delta has been increasing slowly since then. It includes some new mutations affecting the spike protein, which the virus uses to penetrate our cells.

So far, there is no indication that it is considerably more transmissible as a result of these changes, but it is something experts are studying.

The mutations – Y145H and A222V – have been found in various other coronavirus lineages since the beginning of the pandemic.

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Analysis box by Michelle Roberts, health editor

Scientists are constantly checking for new genetic changes that Covid is undergoing.

Some emerging variants are worrying, but many are inconsequential. The difficult job is spotting, tracking and managing the ones that could matter.

The UK is a front-runner in carrying out these vital lab analyses, having completed more than a million tests so far.

The first step is to pick up new mutants worth watching, such as this new offshoot – AY.4.2.

Next, if there is a strong suggestion that the genetic changes might make the virus more contagious, it is classified as a variant under investigation and more checks are done.

If it becomes clearer that it could be more transmissible and escape some of the built up immunity from past infections or vaccines, or potentially cause more serious disease, it is moved into the variant of concern category. That’s the one Delta belongs to.

At this stage, experts don’t think AY.4.2 is likely to take hold – so in time it could well burn out and drop off the watch list.

Prof Francois Balloux, director of University College London’s Genetics Institute, said: “It is potentially a marginally more infectious strain.

“It’s nothing compared with what we saw with Alpha and Delta, which were something like 50 to 60 percent more transmissible. So we are talking about something quite subtle here and that is currently under investigation.

“It is likely to be up to 10 percent more transmissible.

“It’s good that we are aware. It’s excellent that we have the facilities and infrastructure in place to see anything that might be a bit suspicious.

“At this stage I would say wait and see, don’t panic. It might be slightly, subtly more transmissible but it is not something absolutely disastrous like we saw previously.”

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